Cutting Edge: Nucleotide-Binding Oligomerization Domain 1-Dependent Responses Account for Murine Resistance againstTrypanosoma cruziInfection

Cutting edge: nucleotide-binding oligomerization domain 1-dependent responses account for murine resistance against Trypanosoma cruzi infection.

An effective innate immune recognition of the intracellular protozoan parasite Trypanosoma cruzi is critical for host resistance against Chagas disease, a severe and chronic illness that affects millions of people in Latin America. In this study, we evaluated the participation of nucleotide-binding oligomerization domain (Nod)-like receptor proteins in host response to T. cruzi infection and fo...

Nucleotide-Binding Oligomerization Domain

The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses.

Nucleotide-binding oligomerization domain-like receptors (NLRs) are a group of intracellular proteins that mediate recognition of pathogen-associated molecular patterns or other cytosolic danger signals. Mutations in NLR genes have been linked to a variety of inflammatory diseases, underscoring their pivotal role in host defense and immunity. This report describes the genomic organization and r...

Nucleotide-binding oligomerization domain 1 and gastrointestinal disorders

Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular sensor that detects small peptides derived from the cell wall component of intestinal microflora. NOD1 is expressed in both non-hematopoietic cells such as epithelial cells and hematopoietic cells such as antigen-presenting cells. Detection of its ligand by NOD1 leads to innate immune responses through activation of nuclear ...

association of nucleotide-binding oligomerization domain receptors with peptic ulcer and gastric cancer

host innate immunity can affect the clinical outcomes of helicobacter pylori infection, including gastritis, gastric ulcer, gastric adenocarcinoma, and malt lymphoma. nucleotide binding oligomerization domain (nod)-1 and -2 are two molecules of innate immunity which are involved in the host defense against h. pylori . this study aimed to evaluate the effect of the expression level of nod1 and n...